MATERNAL PROTEIN MALNUTRITION DURING LACTATION PREDISPOSES TO A METABOLIC SYNDROME PHENOTYPE IN MALE WISTAR RATS

Maternal nutritional insults during lactation can modulate the offspring phenotype associatedwith risk of non-communicable diseases at different stages ontogenetic development.The aim this research was to analyze biometric and biochemical parameters male Wistarrats, born dams fed a low-protein diet in first two-thirds lactation. Therefore, themothers received ad libitum normal (NP, 23%) or (LP, 4%) diet, originatingtwo experimental groups that were evaluated 14 days old (NP-14 LP-14). The resultsshowed LP-14 rats had lower body weight (p<0.0001), reduced liver(p<0.0001) higher brown fat deposits compared equivalent control.They also exhibited hyperglycemia (p<0.05), hypercholesterolemia increasedserum β-hydroxybutyrate contrasting with triglycerides (p<0.05) levels.We conclude maternal exposure able toprogram 14-day-old neonates develop metabolic syndrome phenotype, probably dueto restriction visceral growth these animals.